CD47 has shown potential as a target for cancer and we believe that a bispecific approach may open up potential for differentiated therapies. We are always looking to use our in-house expertise in novel ways; we look forward to seeing the results from the combination of Genmab’s DuoBody technology with a CD47 antibody from BliNK Biomedical,” said Jan van de Winkel, Ph.D., Chief Executive

Description: Recombinant rabbit monoclonal (CD47/6362R) antibody to CD47. Specificity: This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail.

The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Anti-CD47 Antibody Products. Anti-CD47 antibodies are offered by a number of suppliers. This target gene encodes the protein 'CD47 molecule' in humans and may also be known as IAP, MER6, OA3, leukocyte surface antigen CD47, and CD47 antigen (Rh-related antigen, integrin-associated signal transducer). Structurally, the protein is reported to be Antigen identified by monoclonal antibody 1D8 antibody; Antigenic surface determinant protein OA3 antibody; CD 47 antibody; CD47 antibody; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody; CD47 antigen antibody; CD47 glycoprotein antibody; CD47 molecule antibody; CD47_HUMAN antibody; IAP antibody; Integrin Associated Protein antibody Antibody information for antibodies HPA044659 and CAB016055 used in analysis of ENSG00000196776 / CD47 (IAP, MER6, OA3) The B6H12 monoclonal antibody reacts with human CD47 otherwise known as integrin-associated protein (IAP), and neurophilin.

Anti-CD47 antibody blockade the interaction between macrophage signal regulatory protein-α (SIRPα) and tumor surface CD47. In this study, we reported and assessed a novel anti-CD47 blocking antibody named 2C8, which exhibited high affinity and tremendous anticancer effects. HPA044659 Sigma-Aldrich Anti-CD47 antibody produced in rabbit Prestige Antibodies ® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution . Synonym: Anti-IAP, Anti-MER6, Anti-OA3 Human Protein Atlas Number HPA044659 Human Protein Atlas - View RNA & protein expression data of this target Epitope binning of anti-CD47 antibodies.

T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Recently stimulation of CD47 by monoclonal antibody has been shown to induce CD4+CD25- suppressive activity also increasing expression of Foxp3. Here, we report the identification of CD47, a protein that inhibits phagocytosis, as an antibody target in standard and high-risk ALL. CD47 was found to be more highly expressed on a subset of human ALL patient samples compared with normal cell counterparts and to be an independent predictor of survival and disease refractoriness in several ALL patient cohorts.

19 Jun 2020 Magrolimab is a first-in-kind IgG anti-CD47 monoclonal antibody that promotes the elimination of tumor cells through macrophage phagocytosis

Antibodies were deemed to occupy the same or overlapping epitope bin if the biotinylation signal was reduced. Crystallization and structure determination. CD47-ECD/TJ-C4 complex was co- Antigen identified by monoclonal antibody 1D8 antibody; Antigenic surface determinant protein OA3 antibody; CD 47 antibody; CD47 antibody; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody; CD47 antigen antibody; CD47 glycoprotein antibody; CD47 molecule antibody; CD47_HUMAN antibody; IAP antibody; Integrin Associated Protein antibody Rabbit polyclonal CD47 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human.

CD47 serves as an anti-phagocytic receptor that is upregulated by cancer to promote immune escape. As such, CD47 is the focus of intense immuno-oncology drug development efforts. However, as CD47 is expressed ubiquitously, clinical development of conventional drugs, e.g., monoclonal antibodies, is confronted with patient safety issues and poor pharmacology due to the widespread CD47 “antigen

Antibodies were deemed to occupy the same or overlapping epitope bin if the biotinylation signal was reduced. Crystallization and structure determination.

washing, and 1 h incubation with Alexa647-conjugated secondary antibodies. Tumörceller kan undvika makrofag fagocytos genom CD47-uttryck.
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Anti-CD47 antibodies block the interaction between macrophage signal regulatory protein-α (SIRPα) and tumor surface CD47. In this study, we report and assess a novel anti-CD47 blocking antibody named 2C8, which exhibits high affinity and tremendous anticancer effects. Description: Recombinant rabbit monoclonal (CD47/6362R) antibody to CD47.

A61K39/00; C07K16/28; C07K16/46. NovImmune SA. 2013-12- 2013-11-15.
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Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity Cancer Immunol Immunother. 2020 Aug 6. doi: 10.1007/s00262-020-02679-5. Online ahead of print.

(2009) CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.

Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity Cancer Immunol Immunother. 2020 Aug 6. doi: 10.1007/s00262-020-02679-5. Online ahead of print.

However, as CD47 is expressed ubiquitously, clinical development of conventional drugs, e.g., monoclonal antibodies, is confronted with patient safety issues and poor pharmacology due to the widespread CD47 “antigen Magrolimab is a first-in-class investigational monoclonal antibody against CD47 and macrophage checkpoint inhibitor that is designed to interfere with recognition of CD47 by the SIRPα receptor on macrophages, thus blocking the "don't eat me" signal used by … 2021-04-01 Clone REA170 recognizes CD47, which is also known as integrin-associated protein. CD47 is a 50 KDa heavily glycosylated protein with an extracellular IgV domain, five transmembrane domains and a cytoplasmic tail, which exists in 4 different isoforms. The expression of CD47 varies in different tissue types depending upon the cytoplasmic tail isoform associated, for e.g the 16 amino acid form 2 CD47 (CD47 Molecule) is a Protein Coding gene. Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis. Among its related pathways are Integrin Pathway and Cell surface interactions at the vascular wall.

CD47-ECD/TJ-C4 complex was co- Antigen identified by monoclonal antibody 1D8 antibody; Antigenic surface determinant protein OA3 antibody; CD 47 antibody; CD47 antibody; CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody; CD47 antigen antibody; CD47 glycoprotein antibody; CD47 molecule antibody; CD47_HUMAN antibody; IAP antibody; Integrin Associated Protein antibody Rabbit polyclonal CD47 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Human. Cited in 1 publication(s). Independently reviewed in 3 review(s).